Liposomal Lactoferrin and Liposomal Lactoferrin plus Zinc Induces Antiinflammatory and Immunomodulatory Effects by Activation of IFNγ

International Journal of Research in Health Sciences,2020,8,4,25-31.
Published:December 2020
Type:Research Article
Author(s) affiliations:

Gabriel Serrano1, Iulia Kochergina1, Ricardo Gutiérrez1, Magda Reyes2, Arturo Albors3, Fernando Millan1, Matilde Lorente1, Juan M Serrano4, Guillen Hueso4, Mar Oroval4, Silvia Mir4, Irene MorJ4, Eva Martí4, Pilar Serrano4

1Dr. Serrano Dermatological Clinic, Valencia, Spain

2Dr. Serrano Dermatology Clinic, Bogotá, Colombia

3Medical Department of Sesderma Laboratories, Valencia, Spain

4Research Department of Sesderma Laboratories, Valencia, Spain


The aim of the present study was to evaluate in vitro the anti-inflammatory effects of two products: a liposomal lactoferrin (LLF) solution versus a liposomal lactoferrin-zinc complex (LLF-Zinc) on CD163 and CD14 protein levels, and gene expression of Tumour Necrosis Factor alpha (TNFα), Interleukin 1 beta (IL-1β), Interleukin 6 (IL-6) and Interferon Gamma 8 (IFNγ), after treatment in Peripheral Blood Mononuclear Cells (PBMCs) directly extracted from human volunteers.

Treatment with Liposomal lactoferrin and liposomal lactoferrin plus zinc (LLF-Zinc) in Peripheral Blood Mononuclear Cells (PBMC), activates a cytokine response mediated by IFNγ, that increases defense mechanisms against infection (induced by LPS). This mechanism seems to be different from that triggered by LPS, precisely because of the specific activation of IFNγ by the two products. Interferons (IFN) are a family of cytokines which, upon secretion, play a central role in mediating the innate and adaptive immune response to viral and bacterial challenges. LLF and in specially LLF-Zinc stimulates Interferon anti-viral responses enhancing our natural defenses against microbial insults.

Bar graphs showing TNFα, IL-1β, IL-6 and IFNγ gene expression results after treating Peripheral Blood Mononuclear Cells (PBMC) at 0.01% and 0.05% concentrations