Background: Viral warts persist and recur in spite of the availability of multiple treatment options, causing frustration to patients and physicians. Aims: To study the effectiveness of autoinoculation as a treatment modality in cutaneous warts. Methods: A double-blind, placebo controlled study was carried out. In the treatment group, full thickness warty tissue was excised, minced and implanted in a small dermal pocket. In the control group, warty tissue was only excised and not implanted, though a dermal pocket was made. Patients were evaluated every four weeks with lesion counts .Response was assessed at each visit and at 12 weeks. Results: Forty patients with cutaneous warts (male: female = 25:15) were randomized into autoinoculation and control groups. The number of warts at baseline was comparable in both groups (P = 0.293). Reduction in the number of warts was significantly more in the autoinoculation group (8.50 ± 13.88) than in the control group (10.04 ± 5.80) from 8 weeks onwards (P = 0.010). Complete resolution occurred only in the autoinoculation group, in 68.5% of cases. Adverse effects were seen in 9 patients, including infection of the donor site (5 cases), keloid formation (2) and hypopigmentation (2). Conclusion: Autoinoculation may be an effective therapeutic modality for cutaneous warts.