Introduction: Worldwide the sexually transmitted diseases continue to be a major public health problem. The sexually transmitted diseases are exercising a very adverse effect on human population and most of these diseases are caused due to ignorance or carelessness. Hence a study was conducted to compare the knowledge and attitude regarding the common sexually transmitted diseases among married women at selected urban and rural areas of Palghar, Thane District ( Maharashtra), with a view to develop health education pamphlet. Material and Methods: A descriptive research approach was used to conduct the study. Samples selected by purposive sampling technique and samples size was 250 (125 from urban and 125 from rural). According to the objectives, a tool was prepared. The tool consisted of a structured questionnaire, teaching plan and teaching aids. The obtained data were analysed by using descriptive and inferential statistics like frequency, percentage, mean, standard deviation, unpaired “t” test and chi square. Result: The mean knowledge score of urban married women (12.03) was greater than the mean knowledge score of rural married women (6.30) and the mean attitude score of urban married women (70.64) was greater than the mean attitude score of rural married women (55.140. The mean calculated unpaired ‘t’ value of knowledge was 19.392( P<0.001) and attitude was 17.173 (P<0.001). Conclusion: The present study showed that the knowledge and attitude of urban married women regarding common sexually transmitted diseases were greater than that of rural married women.