Dengue infection is one of the most common mosquito-borne infections caused by Flaviridae. Dengue hemorrhagic fever (DHF) is more serious than dengue fever (DF) due to capillary leakage. The World Health Organization has reported 2.5 billion people live in areas where dengue viruses can be transmitted (WHO, 2009). The aim of our study is is to evaluate electrolyte disturbances in patients with Dengue infection .In this study we include total of 88 clinically diagnosed and serologically confirmed age and sex matched Dengue cases. Serum electrolytes [Sodium, Potassium & Chloride] were measured by electrolyte kit method by using Semi- auto analyser. The mean age of the study group was 24.4±13.7 in which 70.4 % were adults and 29.5% were children .69.3% of the patients are males ,30.6% are females. The amounts of Sodium (p<0.0001)., Potassium (p<0.0001) and Chlorides (p<0.0001) were varied significantly between the control and the patients samples. The study revealed mild hyponatremia and hypokalemia in Dengue confirmed patients and it was analysed that mild hyponatremia is a common electrolyte disturbance and renal involvement is mild in patients with DF Patients.