Familial Adenomatous Polyposis Coli and Adenocarcinoma of the Colon Synchronous Presentation - Case RKotta Devendar Reddyeport

International Journal of Research in Health Sciences,2014,2,2,659-662.
Published:April 2014
Type:Case Report
Author(s) affiliations:

Kotta Devendar Reddy1, Zaheda Kausar2, Naval Kishore3, Amanulla Khan.Mohmmed4, V.V.Sreedhar5, Anunayi.J

1.Associate Professor 2Assistant Professor 3.Associate Professor 4Post Graduate 5.Professor 6Associate Professor

1Upgraded Department of Pathology, Osmania General Hospital, Hyderabad.


Familial adenomatous polyposis (FAP) coli is an autosomal dominant syndrome characterised by germline mutations of adenomatous polyposis coli (APC) gene. A 35 years old male presented with diarrhoea on and off, pain abdomen and weight loss since one year. Upper gastroendoscopy did not reveal any focal lesion. Colonoscopy showed numerous polyps throughout the colon and an ulcerative growth in the rectum. Patient underwent distal proctocolectomy with ileostomy. Excised specimen showed adenomatous polyposis coli with one focus of invasive carcinoma in the rectum. As mentioned in the literature familial adenomatous polyposis coli (FAP) can transform to invasive adenocarcinoma which was true in our case. We present this case because of its rarity.

Adenomatous polyp -Tubular Adenoma (H & E, X10)