Metabolic syndrome and non-alcoholic fatty liver disease association-a study in rural tertiary care centre in north India

Author : Khwaja Saifullah Zafar, A Ahmad, SF Haque

Objective: We intended to establish a clinical association between NAFLD and MS. Materials and Methods: Weight, height, waist circumference, hip circumference, blood pressure and ultrasound of liver were performed .Serum triglyceride, total cholesterol, high density lipoprotein cholesterol and fasting plasma glucose level were measured. Results: A total of 39 patients of which 25 men and 14 women were included.36 (92.3%) were obese, hypertension in 23(65.2%), dyslipidemia in 32(82.1%). Mean value of CRP and TNF-α in hypertensive patients was 2.30.71mg/l and 84.117.8 pg/ml whereas it was 2.30.7mg/l and 87.67.4pg/ml respectively. A significant increase was found in the mean values of TNF-α and CRP with increasing grades of NAFLD (p-value<0.01).Both TNF-α and CRP were higher in patients of MS .Using Pearson΄s correlation significant correlation of TNF-α and CRP was found with MS (r=0.8 and 0.7 respectively). Conclusion: There is a close association between MS and NAFLD. NAFLD was strongly associated with the MS, although it remains unknown whether NAFLD is a cause or effect of MS.

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