Low Adenosine Deaminase Level in Pleural Effusion and itís relation to Malignancy Amongst Population of Central India

Author : Munje Radha P, Gour Sanjay M, Sonawane Nilesh and Bhaskkar Vandana, Muley Sushant

Adenosine deaminase (ADA) level in non -tubercular pleural effusion rarely exceed cut- off set for tubercular effusion. We conducted a study with the aim of study to find correlation of low pleural fluid with disease and ascertain if it can be used as predictor of malignancy. A Retrosepective Obsevational study of Records of Pleural effusion at Respiratory Medicine ward in our institute during period 1st July 2015 to 30 June 2017.Out of this 140 records 40 were identified with a low ADA value ( <40 IU/L), all value measured using same-Colorimetric method. Mean value associated with malignancy was 23.66 IU/L. Low pleural fluid ADA was associated most commonly with malignancy in 20 cases and other causes included synpneumonic effusion and disseminated tuberculosis. Effusion were likely to be malignant when hemorrhagic in colour (p- value is <0.0001) This study concluded that, a low pleural fluid ADA (<40/IU/L) is not useful when used alone as predictor of malignancy .However if low value of ADA is associated with hemorrhagic colour- a caution should be observed to rule out malignancy with further diagnostic workup

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