Background: People with Mental Retardation represent 2 - 3% of the general population. The parents of people with mental retardation seem to be affected considerably and they are exposed more for problems in their family lives. There is interaction between the parents and their children with mental retardation which leads to creation of negative dynamics and causing stress and reactions in the parents of children with disabilities. Methods: The objective of this study is to explore the attitude of the parents towards their children with mental retardation. The study research design is a 4x2x2 factorial design with a sample of 192 respondents. Parental Attitude towards problem children, a scale developed by Rangaswamy was used in the study. Results: Overall mean score obtained from the study indicates that there was a parental negative attitude towards children with mental retardation, and there is a positive correlation of overprotection with education and future, home management and total attitude. Discussion: There is a positive correlation of overprotection with education and future, home management and total attitude. The three main variables of the study (severity of mental retardation, sex and age) when interact with each other do not affect significantly on the parental attitudes towards children with mental retardation. Conclusion: There is a parental negative attitude towards children with mental retardation which is highly on home management and lowest on acceptance.