Anaplastic Carcinoma Thyroid – cytomorphology and Clinical Implications of Two Cases

International Journal of Research in Health Sciences,2015,3,1,214-216.
Published:January 2015
Type:Case Report
Authors:
Author(s) affiliations:

Ezhil Arasi N1, Zaheda Kausar2, Anunayi J3, Puja Deshmukh4

1Professor and Head, Dept. of Pathology, Osmania medical college, Hyderabad, Telangana, INDIA. 

2Assistant Professor, Dept. of Pathology, Osmania medical college, Hyderabad, Telangana, INDIA.  

3Associate Professor, Dept. of Pathology, Osmania medical college, Hyderabad, Telangana, INDIA.  

4Senior Resident, Dept. of Pathology, Osmania medical college, Hyderabad, Telangana, INDIA. 

Abstract:

Anaplastic thyroid carcinoma also called undifferentiated carcinoma is uncommon aggressive tumor of the thyroid and accounts for 1-2% of all Cancers in the thyroid. Herein we present cytomorphological features of 2 cases of anaplastic carcinoma thyroid. Clinically both the cases were of elderly age group and presented with nodular thyroid swelling with recent rapid growth in the size. Fine needle aspiration cytology was done showed pleomorphic giant cells, papillary fronds and follicular structures, diagnosed as anaplastic carcinoma thyroid/poorly differentiated thyroid carcinoma. This variant can arise from well differentiated papillary thyroid carcinoma and is associated with grave prognosis. Hence awareness of this entity with early diagnosis helps in prevention of development of anaplastic carcinoma.

Hematoxylin and eosin stained cytosmears showing pleomorphic thyroid follicular cells in clusters, papillaroid pattern and tumor giant cells