Transfusion of blood and blood products is life saving intervention; at the same time it could be a mode of infection transmission to the recipients. One of the greatest challenges of transfusion medicine is to Screen, Monitor and control TTI. Donor selection and screening of donor’s blood for infective agents was undertaken during the period of Jan2011 to June 2013 a total number of 10,776 units of blood were collected from voluntary and replacement donors. There were10,496 Males and 280 females with a ratio of 37:1 in the age group of 18-60 years. Majority of donors were replacement donors with male preponderance in the age group of 21 to 40 years showing high prevalence rate of Transfusion Transmitted Infections (TTI). A total of 194 units (1.8%) of blood had serological evidence of infection, with Hepatitis-B (HBV) - 134(1.24%), Human Immunodeficiency Virus (HIV)-46 (0.42%), Hepatitis–C (HCV) -11 (0.10%), Syphilis-3 (0.02%). In our study Hepatitis-B was the most prevalent amongst TTI.